Related Experiment Videos
Bispectral index during modified rapid sequence induction using thiopentone or propofol and rocuronium
1Department of Anaesthesiology, University Malaya Medical Centre, Kuala Lumpur 50603, Malaysia.
Anaesthesia and Intensive Care
|April 3, 2004
Summary
Propofol (2 mg/kg) provided deeper anesthesia than thiopental (4 mg/kg) during rapid sequence induction, indicated by lower Bispectral Index (BIS) scores. This suggests propofol may reduce awareness risk during intubation.
Area of Science:
- Anesthesiology
- Neuroscience
- Pharmacology
Background:
- Rapid sequence induction is critical for airway management.
- Thiopental and propofol are common induction agents.
- Bispectral Index (BIS) monitoring assesses anesthetic depth.
Purpose of the Study:
- To compare Bispectral Index (BIS) values between thiopental and propofol during modified rapid sequence induction.
- To evaluate the anesthetic depth and potential awareness risk associated with each agent.
Main Methods:
- Randomized controlled trial with 40 patients.
- Modified rapid sequence induction with thiopental 4 mg/kg or propofol 2 mg/kg.
- Rocuronium 0.6 mg/kg as muscle relaxant.
- Endotracheal intubation at 60 seconds; BIS values recorded for 3 minutes post-induction.
Main Results:
- Propofol group showed significantly higher proportion of subjects with BIS values ≤ 60 at 120, 150, and 180 seconds (P < 0.02, < 0.01, < 0.01).
- All intubations completed within 2 minutes.
- No clinical awareness detected with either agent.
Conclusions:
- Propofol 2 mg/kg is associated with deeper anesthesia compared to thiopental 4 mg/kg during rapid sequence induction.
- Thiopental 4 mg/kg may carry a higher risk of awareness if intubation is delayed or prolonged.
- BIS monitoring is valuable for assessing anesthetic depth during induction.