[Regulation of cerebral blood flow in ischemia]

Cerebral blood flow is dynamic and blood supply changes depending on which brain area is most active in a given moment. Endothelial cells provide information on blood flow autoregulation mechanism of myogenic, metabolic and neurogenic character. In ischaemia, hormonal and humoral regulations play an important role in blood flow, especially those substances which act through endothelial vasoconstricting and vasodilating agents. Depending on ischaemia degree, cerebral ischaemia compensation in done by instant dilation of microcirculatory vessels involving agents regulating muscular tone and vascular diameter. Long-term ischaemia resulting in endothelial cells damage leads to metabolic disturbances in these cells. This, in turn, results in angiostatic and angiogenic agents imbalance (in favour of the latter) which eventually leads to intensified angiogenesis.