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A large-sample QTL study in mice: II. Body composition.

Joao L Rocha1, Eugene J Eisen, L Dale Van Vleck

  • 1Department of Animal Science, University of Nebraska, Lincoln, Nebraska 68583-0908, USA.

Mammalian Genome : Official Journal of the International Mammalian Genome Society
|April 3, 2004
PubMed
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This study identified 50 quantitative trait loci (QTL) influencing mouse growth by analyzing organ and fat weights. Mouse chromosome 2 (MMU2) is highlighted as a significant region for growth and fatness.

Area of Science:

  • Genetics
  • Animal Science
  • Quantitative Trait Genomics

Background:

  • Understanding the genetic basis of complex polygenic traits like growth is crucial.
  • Long-term selection lines for high and low growth in mice provide a valuable model system.

Purpose of the Study:

  • To investigate the genetic architecture of complex polygenic traits in mice.
  • To identify quantitative trait loci (QTL) associated with growth and body composition.

Main Methods:

  • A large-scale F2 intercross experiment with approximately 1,000 mice.
  • Composite interval mapping was performed on data from 552 male F2 mice.
  • Analysis focused on organ weights (heart, liver, kidney, spleen, testis) and adipose depots (subcutaneous, epididymal).

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Main Results:

  • Fifty QTL were detected across 15 mouse chromosomes (MMU) influencing various growth subcomponents.
  • Mouse chromosome 2 (MMU2) contained over 25% of the detected QTL, indicating its importance for growth and fatness.
  • Significant QTL congruency was observed for heart, liver, kidney, and spleen weights, suggesting shared genetic control.

Conclusions:

  • Aggregate growth traits can be effectively understood by dissecting their underlying organ and fat subcomponents.
  • Specific chromosomes, notably MMU2, MMU7, MMU15, and MMU17, are identified as key genetic regions influencing growth and obesity.
  • The genetic architecture of organ weights provides insights into the overall genetic control of body weight.