Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intense selection in an age-structured population.

Alison P Galvani1, Montgomery Slatkin

  • 1Department of Integrative Biology, University of California, Berkeley, CA 94720, USA. agalvani@nature.berkeley.edu

Proceedings. Biological Sciences
|April 3, 2004
PubMed
Summary

Intense, age-specific selection, like from diseases, can significantly alter how quickly advantageous genetic traits evolve in populations with overlapping generations. This impacts understanding evolutionary speed and past selection pressures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The health and economic repercussions of declining MMR coverage in the United States.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Estimating US savings on outpatient prescription pharmaceuticals from international reference pricing.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

The synergy of therapeutic vaccination and timely diagnosis for TB control in high-burden settings: Nunavut as a case study.

Journal of clinical tuberculosis and other mycobacterial diseases·2025
Same author

Racial and Ethnic Disparities in Meningococcal Vaccination Coverage and Disease Burden Among U.S. Adolescents.

The Journal of adolescent health : official publication of the Society for Adolescent Medicine·2025
Same author

Quantifying the mortality and morbidity impact of medicaid work requirements: a modeling study.

Lancet regional health. Americas·2025
Same author

School-Level Gaps in MMR Coverage as the Fuel for Measles Outbreaks.

Annals of internal medicine·2025

Area of Science:

  • Evolutionary biology
  • Population genetics
  • Genetics of disease resistance

Background:

  • Selection intensity and age structure influence allele frequency dynamics.
  • Age-specific selection, common in disease-driven scenarios, can complicate evolutionary predictions.
  • Understanding these factors is crucial for interpreting evolutionary history.

Purpose of the Study:

  • To model the impact of intense, age-specific selection on allele frequency changes.
  • To investigate how temporal selection dynamics affect evolutionary rates.
  • To provide a framework for inferring past selection pressures.

Main Methods:

  • Developed a population genetics model incorporating overlapping generations and age-specific selection.
  • Analyzed the effects of selection intensity and age-specificity on allele frequency trajectories.

Related Experiment Videos

  • Simulated evolutionary dynamics under various selection scenarios.

    • Main Results:

    • Intense selection can perturb population age distributions, affecting allele frequency dynamics.
    • Age-specific selection influences the outcome of selection at specific genetic loci.
    • The speed of evolution is significantly altered by temporal selection dynamics, especially when intense and age-specific.

    Conclusions:

    • Age-specific selection, particularly intense forms like those from diseases, plays a critical role in evolutionary trajectories.
    • The findings have broad implications for understanding the evolution of disease resistance and inferring historical selection pressures.
    • Temporal dynamics of selection are key determinants of evolutionary rates in structured populations.