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Related Experiment Videos

pH stability of ophthalmic solutions.

Monica Garcia-Valldecabres1, Antonio López-Alemany, Miguel F Refojo

  • 1Ocular Surface, Cornea, and Contact Lenses Research Group, Department d'Optica, Universitat de València, València, Spain.

Optometry (St. Louis, Mo.)
|April 3, 2004
PubMed
Summary

This study assessed ophthalmic solutions, finding nine had pH within ocular comfort. Eight solutions had pH between 3.5-6.4, with some showing significant pH changes over time.

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Area of Science:

  • Ophthalmology
  • Pharmaceutical Science
  • Analytical Chemistry

Background:

  • Evaluation of pH in ophthalmic solutions is crucial for ocular comfort and drug efficacy.
  • Understanding pH stability after bottle opening is essential for maintaining product integrity.

Purpose of the Study:

  • To determine the pH values of 17 different ophthalmic solutions.
  • To investigate the pH stability of these solutions over 30 days post-opening.

Main Methods:

  • Random selection of 15 bottles per solution type from various production lots.
  • Daily pH measurement of 0.05-ml aliquots using a micropH 2002 Crison pH-meter for 30 days.

Main Results:

  • Nine solutions exhibited pH within the ocular comfort range; eight had pH between 3.5 and 6.4.
  • Ten solutions showed non-statistically significant pH variations over time (p > 0.01).
  • Seven solutions displayed isolated, statistically significant pH variations.

Conclusions:

  • Solutions with pH within the ocular comfort range are unlikely to cause initial discomfort.
  • Acidic pH solutions may lead to initial ocular discomfort.
  • Solutions demonstrating non-significant pH changes over 30 days exhibit good stability.

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