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Related Experiment Videos

High urinary corticoid/creatinine ratios in cats with hyperthyroidism.

Mabet S de Lange1, Sara Galac, Maartje R J Trip

  • 1Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Journal of Veterinary Internal Medicine
|April 3, 2004
PubMed
Summary

The urinary corticoid to creatinine ratio is elevated in hyperthyroid cats, indicating potential adrenocortical dysfunction. This ratio may normalize after treating hyperthyroidism, suggesting thyroid hormone excess impacts cortisol levels.

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Area of Science:

  • Veterinary Endocrinology
  • Companion Animal Medicine

Background:

  • The urinary corticoid to creatinine ratio (C:C) assesses cortisol secretion and adrenocortical function.
  • Non-adrenal diseases and diagnostic procedures can elevate urinary C:C ratios.
  • Thyroid hormones can influence cortisol metabolism.

Purpose of the Study:

  • To evaluate the effect of hyperthyroidism on urinary C:C ratios in cats.
  • To establish a reference range for urinary C:C ratios in healthy cats.
  • To determine if urinary C:C ratios decrease after hyperthyroidism treatment.

Main Methods:

  • Measured urinary C:C ratios in 32 hyperthyroid cats and 45 healthy cats.
  • Determined reference range (8.0-42.0 x 10^-6) using data from healthy cats.
  • Measured urinary C:C ratios in 7 cats before and after treatment for hyperthyroidism.

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Main Results:

  • Urinary C:C ratios were significantly higher in hyperthyroid cats (median 37.5 x 10^-6) than in healthy cats (median 16 x 10^-6).
  • Fifteen hyperthyroid cats had C:C ratios exceeding the upper limit of the reference range.
  • Treatment for hyperthyroidism resulted in a marked decrease in urinary C:C ratios.

Conclusions:

  • Hyperthyroidism in cats can lead to abnormally high urinary C:C ratios, likely due to increased cortisol clearance and pituitary-adrenocortical axis activation.
  • Hyperthyroidism should be considered and ruled out in cats with high urinary C:C ratios, even with differing clinical signs from hyperadrenocorticism.