Related Experiment Video
Updated: Aug 25, 2026

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics
Published on: September 16, 2022
Preventing pressure ulcers with the Australian Medical Sheepskin: an open-label randomised controlled trial
Damien J Jolley1, Robyn Wright, Sunita McGowan
1School of Health Sciences, Deakin University, Melbourne, Victoria, Australia.
Objective:
To estimate the effectiveness of a new high-performance Australian medical sheepskin (meeting Australian Standard 4480.1-1998) in preventing pressure ulcers in a general hospital population at low to moderate risk of these ulcers.
Design:
Open-label randomised controlled clinical trial.
Setting:
A large metropolitan teaching hospital in Melbourne, Victoria, in 2000.
Participants:
441 patients aged over 18 years admitted between 12 June and 30 November 2000, with expected length of stay over 2 days and assessed as at low to moderate risk of developing pressure ulcers.
Intervention:
Patients were randomly allocated to receive a sheepskin mattress overlay for the duration of their hospital stay (218 patients) or usual treatment, as determined by ward staff (referent group, 223 patients).
Main Outcome Measures:
Incidence rate and cumulative incidence of pressure ulcers, assessed daily throughout hospital stay.
Results:
58 patients developed pressure ulcers (sheepskin group, 21; referent group, 37). Cumulative incidence risk was 9.6% in the sheepskin group (95% CI, 6.1%-14.3%) versus 16.6% in the referent group (95% CI, 12.0%-22.1%). Patients in the sheepskin group developed new pressure ulcers at a rate less than half that of referent patients (rate ratio, 0.42; 95% CI, 0.26-0.67).
Conclusions:
The Australian Medical Sheepskin is effective in reducing the incidence of pressure ulcers in general hospital inpatients at low to moderate risk of these ulcers.

