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Related Experiment Videos

CD34-reactive trichodiscoma.

Molly Chartier1, Michael L Reed, Srinivas Mandavilli

  • 1Department of Dermatology, University of Connecticut Health Center, Dowling South, 263 Farmington Avenue, Farmington, CT 06030, USA.

Journal of Cutaneous Pathology
|April 3, 2004
PubMed
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This study reports a rare solitary trichodiscoma case. Immunohistochemistry revealed strong CD34 expression in spindle cells, aiding differential diagnosis of dermal spindle cell tumors.

Area of Science:

  • Dermatopathology
  • Oncology
  • Histology

Background:

  • Trichodiscomas are rare hamartomas of the hair disc's dermal portion.
  • Typically present as asymptomatic papules, they can be solitary or multiple with autosomal dominant inheritance.

Observation:

  • A 78-year-old woman presented with a solitary, non-pigmented, firm papule on the nose.
  • The lesion measured 3.5 mm in diameter.

Findings:

  • Histological examination confirmed a trichodiscoma.
  • Immunohistochemical analysis demonstrated strong CD34 immunoreactivity in the spindle cell component.
  • Spindle cells were negative for S-100, HMB-45, Melan-A, EMA, neurofilament, desmin, and Factor XIIIa.

Implications:

Related Experiment Videos

  • Strong CD34 reactivity is a key feature of trichodiscoma.
  • This finding is crucial for the differential diagnosis of CD34+ dermal spindle cell proliferations.
  • Consider trichodiscoma when an adjacent epithelial component is possible in CD34+ spindle cell lesions.