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Updated: Aug 11, 2026

Measurement of mRNA Decay Rates in Saccharomyces cerevisiae Using rpb1-1 Strains
Published on: December 13, 2014
Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife
Gabriele Neu-Yilik1, Niels H Gehring, Matthias W Hentze
1Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany. gaby.neu-yilik@med.uni-heidelberg.de
Abstract:
Nonsense-mediated mRNA decay (NMD) downmodulates mRNAs that have in-frame premature termination codons and prevents translation of potentially harmful truncated proteins from aberrant mRNAs. Two new approaches have identified physiological NMD substrates, and suggest that NMD functions as a multipurpose tool in the modulation of gene expression.
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