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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
Hotspots of mammalian chromosomal evolution
Jeffrey A Bailey1, Robert Baertsch, W James Kent
1Department of Genetics, Center for Computational Genomics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH 44106, USA.
Genome Biology
|April 3, 2004
Summary
Chromosomal evolution may not be random. Segmental duplications are significantly associated with rearrangements in the human genome, suggesting predisposed regions for evolutionary changes.
Area of Science:
- Genomics
- Evolutionary Biology
- Comparative Genomics
Background:
- Chromosomal evolution traditionally viewed as random breakage and rearrangement.
- Human and mouse genome sequences enable detailed analysis of breakpoint properties.
Purpose of the Study:
- Investigate sequence properties underlying chromosomal breakpoints.
- Determine if segmental duplications are associated with rearrangements.
Main Methods:
- Analysis of human and mouse genomic sequences.
- Identification and characterization of breakpoints in syntenic blocks.
- Statistical comparison with simulated random-breakage models.
Main Results:
- 25% of human genome breakpoints are associated with primate-specific segmental duplications (>10 kb).
- This association is statistically significant (p < 0.0001) and robust.
- Similar associations found in mouse lineage breakpoints.
Conclusions:
- Segmental duplications are linked to syntenic rearrangements, excluding specific regions.
- Segmental duplications may not directly cause rearrangements but are associated with them.
- Mammalian chromosomal evolution may involve nonrandom processes with predisposed regions for duplication and rearrangement.
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