Related Experiment Video
Updated: Oct 9, 2026

The Analysis of Purkinje Cell Dendritic Morphology in Organotypic Slice Cultures
Published on: March 21, 2012
'Dark' cell formation under protein malnutrition: process of conversion and concept of 'semi-dark' type Purkinje
T J James1, S P Sharma, S K Gupta
1Department of Zoology, Kurukshetra University, India.
Abstract:
This paper deals with some deleterious effects of protein malnourishment in rat cerebellum. Severe protein deprivation enhanced the formation of 'dark' cells in white rats. It is postulated that abnormal changes in the neuronal contents induced by nutritional stress play a vital role in the formation of the 'dark' cells through an intermediary stage, 'semi-dark' cells. Centrophenoxine a lipofuscinolytic agent, however, seems to interfere with the process of formation of 'dark' cells and/or helps reconversion of the 'dark' cells into the normal or 'light' type Purkinje cells.
More Related Videos
Related Concept Videos
Formation of Muscle Fibers from Myoblasts
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription factors...
Photoreceptors and Visual Pathways
Cellular Adaptation I: Introduction and Atrophy

