Related Experiment Video
Updated: Aug 1, 2026

12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Dermatonecrotic lesions in rabbits caused by neuraminidase
I V Isupov1, O F Sagheyeva, Yeliseyev YuYu
1Department of Pathohistology, Russian State Antiplague Research Institute, Microbe, Saratov.
The Indian Journal of Medical Research
|May 1, 1992
Abstract:
In an attempt to study the role of neuraminidase in cholera vibrio pathogenesis, the dermatonecrotic effect of a purified neuraminidase preparation was studied in rabbits. The experiments demonstrated that dermatonecrotic lesions resulted from intracutaneous injection of a purified neuraminidase preparation (0.5 specific human dose or 1 NU) as well as significant doses of cholera toxoid containing the enzyme (4,12,18 specific human doses).

