Related Experiment Videos
Plasma lipid peroxides in coronary heart disease
1Department of Biochemistry, Medical School, University of Indonesia, Jakarta.
Insights
Plasma lipid peroxide levels were significantly higher in patients with coronary heart disease, indicating its potential as a marker for disease severity.
Area of Science:
- Cardiology
- Biochemistry
- Internal Medicine
Background:
- Coronary heart disease (CHD) remains a leading cause of mortality globally.
- Investigating biomarkers for CHD severity is crucial for effective patient management.
- Plasma lipid peroxide's role in CHD pathogenesis requires further elucidation.
Purpose of the Study:
- To investigate the association between plasma lipid peroxide levels and coronary heart disease (CHD).
- To assess plasma lipid peroxide as a potential determinant of CHD severity.
- To explore the relationship between traditional CHD risk factors and plasma lipid peroxide.
Main Methods:
- A case-control study involving 98 patients (47 angina, 22 myocardial infarction) and controls.
- Plasma lipid peroxide levels were measured and compared between patient groups and controls.
- Analysis included assessment of traditional cardiovascular risk factors (smoking, hypertension, diabetes, etc.).
Main Results:
- Plasma lipid peroxide levels were significantly elevated in patients with angina and myocardial infarction compared to controls (p < 0.05).
- No significant differences in total cholesterol, LDL, or triglycerides were observed between groups.
- HDL cholesterol was higher in angina patients compared to myocardial infarction patients.
Conclusions:
- Elevated plasma lipid peroxide is associated with coronary heart disease.
- Plasma lipid peroxide may serve as a useful determinant in assessing CHD severity.
- Further research into antioxidant interventions for CHD patients is warranted.
Abstract:
The relation between plasma lipid peroxide and coronary heart disease was investigated at Harapan Hospital in Kita Jakarta. Ninety-eight patients (83 males and 15 females), below 75 years old were included in the study. The samples consisted of 47 cases with angina and 22 cases with myocardial infarction which were proven to suffer from coronary atherosclerosis by the presence of clinical symptoms, ECG abnormalities, angiography and myocardial enzyme measurement. Controls were patients who did not show any abnormalities in the parameters used. Controls and patients were classified into several groups based on the presence or absence of risk factors (smoking, hypertension, diabetes mellitus, hyperlipidemia, obesity, family history). The results of the study showed that plasma lipid peroxide in patients with angina and myocardial infarction which were 3.26 +/- 1.07 mumol and 3.20 +/- 0.82 mumol/l, respectively, were significantly higher (p less than 0.05) than controls 2.50 +/- 0.45 mumol/l. There was no differences in total cholesterol, LDL and triglyceride contents between control and patients with coronary heart disease; whereas HDL cholesterol level was significantly higher in the patients with angina, 38.7 +/- 10.5 mg/dl vs 31.5 +/- 6.76 mg/dl in patients with myocardial infarction. Univariate analysis of various risk factors revealed a strong correlation between plasma lipid peroxide and the chance in developing coronary heart disease. The present study showed that plasma lipid peroxide was increased in coronary heart disease and that it might be used as a determinant in the assessment of the severity of the disease. An investigation on the effects of antioxidants in these patients is planned.