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Collagen, ageing and nutrition
1University of Saint-Etienne, Saint-Etienne, France. jacfrey@free.fr
Clinical Chemistry and Laboratory Medicine
|April 6, 2004
Abstract:
The relationship between ageing and nutrition is considered with collagen as the intermediate target. Some data showed that diet restriction resulted in decreased collagen accumulation and collagen ageing. Conversely, being overweight reduced the lifespan and increased collagen ageing. Collagen ageing, which includes low turnover and glycoxidation, involves an increase in both stiffness and weakness. Their consequences concern all tissues including those with vital importance such as cartilage, heart ventricle or arterial wall.
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