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Published on: July 28, 2023
Risk factors for Helicobacter pylori infection in children: is education a main determinant?
E D Moreira1, R S Santos, V B Nassri
1Núcleo de Apoio à Pesquisa, Associação Obras Sociais Irmã Dulce, Salvador, Bahia, Brazil.
Insights
Higher educational attainment in caregivers may prevent Helicobacter pylori (Hp) infection in children. Poor sanitation, thumb sucking, and pet dogs were associated risk factors for Hp infection.
Area of Science:
- Pediatrics
- Infectious Diseases
- Epidemiology
Background:
- Helicobacter pylori (Hp) infection is a significant global health concern, particularly in pediatric populations.
- Understanding risk factors is crucial for developing effective prevention strategies.
Purpose of the Study:
- To identify risk factors associated with Helicobacter pylori infection in hospitalized children in Salvador, Brazil.
- To explore the relationship between socioeconomic and behavioral factors and Hp infection.
Main Methods:
- A case-control study involving 167 hospitalized children.
- Hp infection diagnosed via IgG antibody detection in serum.
- Data collected through structured questionnaires.
Main Results:
- 38.3% of children were seropositive for Hp infection.
- Independent risk factors included poor garbage disposal, thumb sucking, having a pet dog, and a history of chronic urticaria.
- Higher educational attainment of the child's provider (≥11 years) was associated with a reduced risk of Hp infection (OR 0.1).
Conclusions:
- Findings suggest a complex transmission pattern for Hp, potentially involving both oral-oral and fecal-oral routes.
- Higher caregiver education appears to be a protective factor against Hp infection.
- Public health interventions should consider socioeconomic factors and hygiene practices in Hp prevention efforts.
Abstract:
To investigate potential risk factors associated with Helicobacter pylori (Hp) infection, we performed a case-control study in 167 consecutively selected hospitalized children in Salvador, Brazil. Hp infection was identified by the presence of IgG against Hp in serum samples. Data were gathered using a structured questionnaire, 38.3% children were found to be seropositive and classified as cases, and 61.7% were seronegative controls. After multivariate analysis, independent variables associated with Hp infection included: the educational attainment of the child's provider > or = 11 years (OR 0.1, 95% CI 0.01-0.9), poor garbage disposal service (OR 2.2, 95% CI 1.0-4.9), thumb sucking (OR 4.6, 95% CI 1.1-19.8), brushing teeth more than once a day (OR 5.6, 95% CI 1.8-17.7), having a pet dog (OR 2.5, 95% CI 1.0-6.1), and a history of chronic urticaria (OR 4.0, 95% CI 1.5-10.8). The risk factors identified are consistent with some, but not all, previous studies supporting either oral-oral or faecal-oral transmission of Hp. Our data suggested that a higher educational attainment might play an important role in preventing Hp infection.
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