Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement and immunity.

Hector Molina1

  • 1Division of Rheumatology, Department of Medicine, Washington University School of Medicine, Box 8045, CSRB 6604, 4940 Parkview Place, St. Louis, MO 63110, USA. hmolina@imgate.wustl.edu

Rheumatic Diseases Clinics of North America
|April 6, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Butyrate suppresses mucosal inflammation in inflammatory bowel disease primarily through HDAC3 inhibition in monocytes and macrophages.

The FEBS journal·2025
Same author

Optimization of lung tissue pre-treatment by bead homogenization for subsequent culturomics.

Scientific reports·2024
Same author

Regulation of the Intestinal Extra-Adrenal Steroidogenic Pathway Component LRH-1 by Glucocorticoids in Ulcerative Colitis.

Cells·2022
Same author

Transcriptomic profiles reveal differences in zinc metabolism, inflammation, and tight junction proteins in duodenum from cholesterol gallstone subjects.

Scientific reports·2020
Same author

Basic suture techniques for medicine students: comparative results according to training by surgeons versus peers.

Cirugia y cirujanos·2019
Same author

Effect of cholecystectomy on bile acid synthesis and circulating levels of fibroblast growth factor 19.

Annals of hepatology·2015
Same journal

Rheumatology at the Threshold of Artificial Intelligence.

Rheumatic diseases clinics of North America·2026
Same journal

Foreword.

Rheumatic diseases clinics of North America·2026
Same journal

Artificial Intelligence Regulation in the United States: Current Landscape and Implications for Rheumatology.

Rheumatic diseases clinics of North America·2026
Same journal

The Role of Artificial Intelligence in Medical Education and Training: Implications for Rheumatology.

Rheumatic diseases clinics of North America·2026
Same journal

Sources of Bias in Clinical Artificial Intelligence and Applications in Rheumatology.

Rheumatic diseases clinics of North America·2026
Same journal

Toward Bridging the Gap from Artificial Intelligence in Clinical Research to Clinical Practice in Rheumatology: The Mayo Experience.

Rheumatic diseases clinics of North America·2026
See all related articles

The immune system identifies and eliminates foreign invaders. This review details the complement system's activation, its role in inflammation and autoimmunity, and potential therapeutic applications.

Area of Science:

  • Immunology
  • Biochemistry

Background:

  • The human body constantly interacts with its environment, encountering foreign substances (antigens) like pathogens and macromolecules.
  • The immune system's primary functions include distinguishing self from non-self and eliminating harmful invaders to maintain health.
  • The complement system is a critical component of the innate immune response, crucial for host defense.

Purpose of the Study:

  • To elucidate the mechanisms of complement system activation.
  • To characterize the consequences of complement activation.
  • To explore the role of the complement system in inflammation and autoimmunity and discuss therapeutic implications.

Main Methods:

  • Review of scientific literature on complement system activation pathways.
  • Analysis of the biological outcomes following complement activation.

Related Experiment Videos

  • Examination of the involvement of complement in inflammatory and autoimmune diseases.

    • Main Results:

    • Detailed description of complement activation pathways (classical, lectin, alternative).
    • Explanation of complement's effector functions, including opsonization, inflammation, and cell lysis.
    • Evidence linking complement dysregulation to various autoimmune conditions and inflammatory processes.

    Conclusions:

    • The complement system is a multifaceted defense mechanism with significant roles in immunity.
    • Understanding complement activation and its role in disease is vital for developing targeted therapies.
    • Therapeutic strategies targeting the complement system hold promise for treating autoimmune and inflammatory disorders.