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Updated: Jan 20, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
[The association between infection of Epstein-Barr virus and chronic periodontitis]
Ying Li1, Jin-cai Zhang, Yun-hui Zhang
1Department of Periodontology and Oral Medicine, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China. zjcwcums@mail.sc.cninfo.net
Objective:
To investigate the relationship between Epstein-Barr virus (EBV) infection and chronic periodontitis.
Methods:
In 62 chronic periodontitis patients, subgingival plaque samples were collected from active periodontitis site, quiescent periodontitis site, and initial gingivitis sites of each subject. The nested polymerase chain reaction (nested-PCR) was used to determine the presence of EBV.
Results:
The EBV was detected in 58.0% of the samples from active periodontitis sites, which was significantly higher than that from quiescent periodontitis sites (58.0% vs 22.6%, P < 0.01) and from initial gingivitis sites (58.0% vs 19.4%, P < 0.01).
Conclusion:
The results suggest that EBV infection is associated with the activity of chronic periodontitis.
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