[Characteristics of cardiac arrhythmia in patients with hypertrophic cardiomyopathy]
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Published on: April 21, 2014
Yan Wang1, Ying-hua Cui, Dao-wen Wang
1Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Insights
Most hypertrophic cardiomyopathy (HCM) patients experience arrhythmias, with bradycardia being more prevalent in those with specific hypertrophy patterns. These arrhythmias, including bradycardia, may contribute to syncope and sudden cardiac death in HCM patients.
Area of Science:
- Cardiology
- Electrophysiology
- Cardiac Pathology
Context:
- Hypertrophic cardiomyopathy (HCM) is a complex cardiac condition.
- Arrhythmias are a significant concern in HCM patients.
- Understanding arrhythmia patterns is crucial for risk stratification.
Purpose:
- To investigate the prevalence and types of arrhythmias in HCM patients.
- To explore the relationship between arrhythmias and cardiac pathology in HCM.
- To determine if specific hypertrophy patterns correlate with particular arrhythmias.
Summary:
- 87% of 85 HCM patients exhibited arrhythmias, including tachycardia (35.3%) and bradycardia (24.7%).
- Patients with a history of syncope showed significantly higher rates of intraventricular conduction block, tachycardia, and bradycardia compared to those without.
- Bradycardia was more common in patients with hypertrophy in the mid-low interventricular septum and cardiac apex.
Impact:
- Identifies bradycardia as a significant arrhythmia in HCM, potentially contributing to syncope and sudden cardiac death.
- Highlights the association between specific hypertrophy locations and increased arrhythmia risk.
- Provides insights for improved monitoring and management strategies for HCM patients.
Objective:
To investigate the patterns of arrhythmias in patients with hypertrophic cardiomyopathy (HCM) and its relation with the pathology of heart.
Methods:
The clinical data, electrical cardiogram (ECG), Holter ECG recordings, and echocardiograms of 85 patients with HCM were collected and analyzed.
Results:
Seventy four (87%) of the 85 patients with HCM had various forms of arrhythmia, including tachycardia in 30 patients with a prevalence of 35.3%, and bradycardia in 21 patients with a prevalence of 24.7%. The incidence rates of intraventricular conduction block and tachycardiac arrhythmia of the 24 HCM patients with syncope history were 45.8% and 50.0% respectively, both significantly higher than those of the 61 HCM patients without syncope history (21.3% and 26.2% respectively, both P > 0.05). The incidence rate of bradycardiac arrhythmia of the 24 HCM patients with syncope history was 50.0%, significantly higher than that of the 61 patients without syncope history (14.8%, P < 0.001). Arrhythmia, especially bradycardia, was more frequent in the patients with hypertrophy in mid-low part of interventricular septum and cardiac apex.
Conclusion:
Most patients with HCM have various cardiac arrhythmias, and occurrence of syncope and cardiac sudden death in the patients may be caused not only by tachycardia but also by bradycardia. Bradycardia is more frequent in the patients with hypertrophy in mid-low part of interventricular and cardiac apex.
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