[Immunotherapy of metastatic renal cell carcinoma: report of 28 cases]
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Updated: Aug 25, 2026
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Hui-jun Wang1, Hai Wang, Han-zhong Li
1Department of Urology, Peking Union Medical College Hospital, Beijing 100230, China.
Objective:
To determine the efficacy of IL-2, IFN and Furtulon in patients with metastatic renal cell carcinoma.
Methods:
During the induction phase of the treatment of 28 patients, which lasted 3 months, IL-2 and IFN were administered subcutaneously three times a week at doses of 5 - 20 MU/m(2) and 6 - 9 MU/m(2), Furtulon was administered at doses of 800 - 1,200 mg daily by oral during 28 days a month.
Results:
The response rate was 46.4%, including 4 complete response (CR), 9 presented with partial response (PR).
Conclusion:
The three-drugs combination described in this study demonstrates activity. Based on the present data, combined biochemotherapy may be a promising new approach to the therapy of the metastatic renal cell carcinoma.
