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Updated: Aug 25, 2026
Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
Published on: May 2, 2022
[Effect of c-kit gene mutation on prognosis of gastrointestinal stromal tumor]
Da-lie Ma1, Xiao-hong Liu, Chen-guang Bai
1Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Objective:
To evaluate the clinical signification of c-kit gene mutation in gastrointestinal stromal tumor (GIST) and examine whether the presence of mutation of c-kit gene is important as a prognostic factor.
Methods:
The c-kit mutation had been detected by PCR-SSCP, DNA sequence, statistical comparison were used for the relationship of c-kit gene mutation and clinical pathology, clinical behavior, recurrence, et al.
Results:
The presence of c-kit mutation correlated with tumor size, proliferating cell nuclear antigen index, mitotic cell number, presence of necrosis, microscopic invasion to adjacent tissues, recurrence and distant metastasis. The age, sex, location of tumor, cell type, the presence of hemorrhage, and c-kit expression were independently related to the presence of c-kit mutation.
Conclusions:
The c-kit gene mutation is an important prognostic factor for GIST.
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