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Updated: Feb 26, 2026

Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung

Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung

Published on: May 20, 2019

Chemotherapy-induced lung disease.

Andrew H Limper¹

¹Thoracic Diseases Research Unit, Division of Pulmonary, Critical Care and Internal Medicine, Mayo Clinic and Foundation, 8-24 Stabile, Rochester, MN 55905, USA. limper.andrew@mayo.edu

Clinics in Chest Medicine

|April 6, 2004

Summary

This summary is machine-generated.

Chemotherapy can cause lung injury. Diagnosis involves excluding infections and cancer recurrence, with treatment often including drug withdrawal and corticosteroids.

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Area of Science:

Pulmonary Medicine
Oncology
Pharmacology

Background:

The lungs are susceptible to injury from various chemotherapy drugs.
Clinicians must recognize known and emerging drug-induced pulmonary toxicities.
Chemotherapy-associated lung disease (CALD) diagnosis is challenging in immunocompromised patients.

Purpose of the Study:

To highlight the risks of chemotherapy-induced lung injury.
To emphasize diagnostic challenges in immunocompromised patients.
To outline potential management strategies for CALD.

Main Methods:

Review of literature on chemotherapy-associated lung disease.
Discussion of diagnostic criteria and differential diagnoses.
Analysis of treatment responses to drug withdrawal and corticosteroids.

Main Results:

Chemotherapy agents pose significant risks to lung function.
Differential diagnosis of CALD requires excluding infections and cancer recurrence.
CALD can be managed by discontinuing the causative agent and using corticosteroids.

Conclusions:

Awareness of pulmonary toxicities from chemotherapy is crucial for clinicians.
Diagnostic exclusion of other conditions is key in managing suspected CALD.
Prompt intervention with drug withdrawal and steroids can improve outcomes.