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Related Experiment Videos

Determining drug spatial distribution within controlled delivery tablets using MFX imaging.

Sean P Rigby1, Christopher F Van der Walle, James H Raistrick

  • 1Department of Chemical Engineering, University of Bath, Claverton Down, Bath BA2 7AY, UK. S.P.Rigby@bath.ac.uk

Journal of Controlled Release : Official Journal of the Controlled Release Society
|April 6, 2004
PubMed
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Micro-focus X-ray (MFX) imaging revealed drug distribution in HPMC tablets is not homogeneous. This technique assesses drug mixing, crucial for quality control in drug delivery systems.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Imaging Technology

Background:

  • Drug delivery systems require precise control over drug distribution for efficacy.
  • Homogeneous drug distribution is a key quality control parameter in tablet manufacturing.
  • Traditional methods may lack the resolution to assess micro-scale drug distribution.

Purpose of the Study:

  • To demonstrate the utility of micro-focus X-ray (MFX) imaging for drug delivery system design.
  • To evaluate the spatial distribution of amiodarone within hydroxypropylmethylcellulose (HPMC) tablets.
  • To assess the effectiveness of mixing processes in pharmaceutical manufacturing.

Main Methods:

  • Utilized micro-focus X-ray (MFX) imaging to map drug distribution.
  • Analyzed amiodarone distribution within HPMC controlled-release tablets (10 mm diameter).

Related Experiment Videos

  • Investigated drug particle distribution at length scales of 10-100 micrometers.

    • Main Results:

    • MFX imaging revealed non-homogeneous spatial distribution of amiodarone.
    • Despite vigorous mixing, drug particles (180-420 microm) formed concentrated patches up to 1 mm.
    • These patches were scattered across the tablet, indicating localized aggregation.

    Conclusions:

    • MFX imaging is a valuable tool for assessing drug distribution in delivery systems.
    • The study highlights potential issues in powder mixing during tablet manufacturing.
    • MFX imaging provides insights for optimizing drug formulation and manufacturing processes.