Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Historical review: Endothelin.

Tomoh Masaki1

  • 1Osaka Seikei University, 3-10-62 Aikawa Higashi-Yodogawa-ku, Osaka City, 533-0007, Japan. masakitt@osaka-seikei.ac.jp

Trends in Pharmacological Sciences
|April 6, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endothelin and endothelial dysfunction.

Proceedings of the Japan Academy. Series B, Physical and biological sciences·2015
Same author

Endothelin XIII.

Life sciences·2014
Same author

Brefeldin A is an estrogenic, Erk1/2-activating component in the extract of Agaricus blazei mycelia.

Journal of agricultural and food chemistry·2012
Same author

Endothelin XII.

Life sciences·2012
Same author

Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract.

Microbiological research·2011
Same author

Lagerstroemia speciosa extract inhibit TNF-induced activation of nuclear factor-kappaB in rat cardiomyocyte H9c2 cells.

Journal of ethnopharmacology·2010

Endothelin (ET), a peptide regulating blood vessel constriction, is crucial for cardiovascular homeostasis. Recent research reveals its significant role in neural crest development and organ formation, opening new research directions.

Area of Science:

  • Cardiovascular Physiology
  • Molecular Biology
  • Developmental Biology

Background:

  • Endothelin (ET) is a potent vasoconstrictive peptide initially isolated from endothelial cells.
  • Key molecular components of the ET system, including isoforms, receptors, and the endothelin-converting enzyme (ECE), have been identified and cloned.
  • ET was initially recognized for its critical role in maintaining cardiovascular homeostasis.

Observation:

  • Research has extensively explored the physiological and pathophysiological significance of ET, particularly in cardiovascular diseases.
  • ET receptor antagonists and ECE inhibitors have been rapidly developed as potential therapeutics for cardiovascular conditions.
  • Molecular biology studies have uncovered novel functions of the ET system.

Findings:

Related Experiment Videos

  • The ET system plays a critical role in the early development of the neural crest.
  • This involvement in neural crest development is essential for proper organ formation.
  • ET's functions extend beyond cardiovascular regulation into developmental processes.

    • Implications:

    • The discovery of ET's role in embryogenesis necessitates a re-evaluation of its overall biological significance.
    • New therapeutic targets and research avenues may emerge from understanding ET's developmental functions.
    • This expands the potential applications of ET-targeting drugs beyond cardiovascular diseases.