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Related Experiment Videos

Bioavailability of vitamin E compounds in lambs.

N Hidiroglou1, L R McDowell, A M Papas

  • 1Department of Surgery, East Tennessee State University, Johnson City 37604.

Journal of Animal Science
|August 1, 1992
PubMed
Summary

This study evaluated vitamin E bioavailability in lambs, finding D-alpha-tocopheryl acetate combined with TPGS showed synergistic effects and the highest bioavailability. Other forms like D-alpha-tocopheryl succinate and DL-alpha-tocopheryl nicotinate also demonstrated varying levels of absorption.

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Area of Science:

  • Animal Nutrition
  • Nutritional Biochemistry
  • Pharmacokinetics

Background:

  • Vitamin E is crucial for animal health, with various supplemental forms available.
  • Understanding the bioavailability of different vitamin E compounds is essential for optimizing animal diets.
  • The absorption and utilization efficiency can vary significantly based on the chemical form of vitamin E.

Purpose of the Study:

  • To compare the bioavailability of different vitamin E compounds in lambs.
  • To investigate potential synergistic effects between vitamin E forms and TPGS.
  • To identify the most effective vitamin E supplement for lambs.

Main Methods:

  • Forty lambs were divided into eight groups, receiving different vitamin E supplements or a control diet for 60 days.

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  • Serum alpha-tocopherol concentrations were monitored throughout the study.
  • Bioavailability was assessed using parameters like Cmax, Ct, area under the concentration-time curve, and pooled increment.

    • Main Results:

    • All supplemented groups showed higher serum alpha-tocopherol than controls.
    • D-alpha-tocopheryl acetate + TPGS exhibited the highest bioavailability, suggesting a synergistic interaction.
    • D-alpha-tocopheryl acetate alone had superior bioavailability compared to most other forms.
    • TPGS alone showed lower bioavailability than other tested forms.

    Conclusions:

    • D-alpha-tocopheryl acetate, especially when combined with TPGS, offers enhanced vitamin E bioavailability in lambs.
    • The combination of D-alpha-tocopheryl acetate and TPGS demonstrates a synergistic effect, improving absorption.
    • Different vitamin E forms possess distinct bioavailability profiles in lambs, impacting their efficacy.