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Related Experiment Videos

Early ovarian ageing.

D Nikolaou1, A Templeton

  • 1Chelsea and Westminster Hospital, Imperial College, London, UK. dnikolaou@talk21.com

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|April 6, 2004
PubMed
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Women experiencing early menopause may have declining fertility from age 32. Early ovarian ageing affects up to 10% of women and is suitable for screening using ovarian reserve tests.

Area of Science:

  • Reproductive biology
  • Epidemiology
  • Assisted reproduction

Background:

  • The interval between accelerated ovarian reserve decline and menopause appears fixed.
  • Early ovarian ageing, defined as menopause by age 45, may indicate fertility decline starting before age 32.

Purpose of the Study:

  • To highlight early ovarian ageing as a screenable condition.
  • To identify potential screening tools for early ovarian ageing.

Main Methods:

  • Review of reproductive biology, epidemiology, and assisted reproduction data.
  • Evaluation of ovarian reserve tests developed using IVF models.

Main Results:

  • Early ovarian ageing affects up to 10% of the general population.

Related Experiment Videos

  • Ovarian reserve tests show promise for screening asymptomatic women.
  • Women with a family history of early menopause are a high-risk group.

    • Conclusions:

    • Early ovarian ageing has a predictable natural history, making it suitable for screening.
    • Ovarian reserve tests may enable early detection of declining fertility in asymptomatic women.