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Related Experiment Videos

The lymph node ratio as prognostic factor in node-positive breast cancer.

Mia Voordeckers1, Vincent Vinh-Hung, Jan Van de Steene

  • 1Department of Radiotherapy, Academic Hospital V.U.B., Laarbeeklaan 101, Brussels, Belgium.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
|April 6, 2004
PubMed
Summary

The ratio of positive lymph nodes in breast cancer patients significantly impacts survival rates. This nodal involvement percentage is a more crucial prognostic factor than the absolute number of affected nodes.

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Area of Science:

  • Oncology
  • Surgical Pathology

Background:

  • Node-positive breast cancer presents a significant challenge in determining patient prognosis.
  • Accurate prognostic indicators are crucial for tailoring treatment strategies.

Purpose of the Study:

  • To investigate the correlation between the ratio of involved axillary lymph nodes (pN+%) and survival outcomes in node-positive breast cancer patients.
  • To determine if pN+% is a superior prognostic factor compared to the absolute number of involved nodes (pN+).

Main Methods:

  • Retrospective analysis of 810 node-positive invasive breast carcinoma cases diagnosed between 1984 and 2001.
  • Categorization of patients into three groups based on pN+% (< or =10%, 11-50%, 51-100%).
  • Univariate and multivariate Cox proportional hazards models were used to assess survival data.

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Main Results:

  • Overall survival (OS) at 5 and 10 years was 78.2% and 59.1%, respectively; cause-specific survival (CSS) was 83.6% and 69.1%.
  • Univariate analysis identified age, grade, pT-stage, chemotherapy, pN+, and pN+% as significant prognostic factors for OS.
  • Multivariate analysis revealed pN+% as the most significant prognostic factor, with pN+ losing significance when pN+% was included.

Conclusions:

  • The percentage of positive lymph nodes (pN+%) in axillary lymph node dissection is a critical prognostic factor for breast cancer survival.
  • pN+% provides improved prognostic assessment compared to the absolute number of involved axillary lymph nodes (pN+).