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Related Experiment Videos

Sciatic nerve stimulation does not increase endogenous adenosine production in sensory-motor cortex.

F J Northington1, G P Matherne, S D Coleman

  • 1Department of Physiology, University of Virginia, Charlottesville.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|September 1, 1992
PubMed
Summary

Adenosine does not appear to regulate brain blood flow during sensory stimulation. However, it may play a role in maintaining normal cerebral blood flow in the resting state.

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Area of Science:

  • Neuroscience
  • Physiology
  • Pharmacology

Background:

  • Adenosine is involved in regulating brain blood flow during conditions like hypoxia and seizures.
  • Its role in cerebral blood flow during sensory stimulation, where blood flow and oxygen consumption are uncoupled, is unclear.

Purpose of the Study:

  • To investigate the role of adenosine in regulating cerebral blood flow during somatosensory stimulation.
  • To determine if adenosine mediates changes in cerebral blood flow in the basal state.

Main Methods:

  • Microdialysis was used to measure interstitial adenosine levels in the hindlimb sensory-motor cortex.
  • Cerebral blood flow was measured using the hydrogen clearance technique during sciatic nerve stimulation.
  • The adenosine antagonist 8-sulfophenyltheophylline was infused to assess its effects.

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Main Results:

  • Cerebral blood flow significantly increased during sciatic nerve stimulation without a change in interstitial adenosine.
  • Infusion of 8-sulfophenyltheophylline did not block the increase in cerebral blood flow during stimulation.
  • The adenosine antagonist decreased basal cerebral blood flow.

Conclusions:

  • Adenosine does not appear to mediate the changes in cerebral blood flow observed during somatosensory stimulation.
  • Adenosine may play a role in regulating basal cerebral blood flow.