Jove
Visualize
Contact Us

Related Experiment Videos

Relationships between lipid availability and protein utilization during prolonged fasting.

Y Cherel1, J P Robin, A Heitz

  • 1Laboratoire d'Etude des Régulations Physiologiques, associé à l'Université Louis Pasteur, Centre National de la Recherche Scientifique, Strasbourg, France.

Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simple and rapid formic acid sample treatment for the isolation of HgSe nanoparticles from animal tissues.

Analytica chimica acta·2023
Same author

Reliability of deep branch of ulnar nerve identification in interosseous-to-ulnar motor nerve transfer: A cadaver study of 20 wrists.

Hand surgery & rehabilitation·2021
Same author

Large-scale survey of lithium concentrations in marine organisms.

The Science of the total environment·2020
Same author

Influence of sexual dimorphism on stable isotopes and trace element concentrations in the greater hooked squid Moroteuthopsis ingens from New Zealand waters.

Marine environmental research·2020
Same author

Antarctic petrels 'on the ice rocks': wintering strategy of an Antarctic seabird.

Royal Society open science·2020
Same author

Combined use of two supervised learning algorithms to model sea turtle behaviours from tri-axial acceleration data.

The Journal of experimental biology·2018
Same journal

Histomorphometric plasticity in pectoral muscles and adipose tissue of Redheaded Bunting in response to skeleton photoperiod.

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology·2026
Same journal

Insects in variable environments: thermal performance, standard metabolic rate, and strategies to escape its limitations.

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology·2026
Same journal

Carbohydrate handling in frugivorous tambaqui (Colossoma macropomum): enzymatic and glycemic responses to dietary sugars.

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology·2026
Same journal

Survival and osmoregulatory capacity of green crabs (Carcinus maenas) invasive to Canadian Pacific estuaries throughout acute freshwater exposure.

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology·2026
Same journal

Estimating behavioral multipliers to American black duck and lesser scaup resting metabolic rate to better estimate daily energy expenditure.

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology·2026
Same journal

Chronic ammonia nitrogen induces integrated metabolic and immune reprogramming in the hepatopancreas of Macrobrachium rosenbergii.

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Obese rats conserve protein more effectively during fasting than lean rats, but experience greater total protein loss. This suggests obesity may lead to lethal protein depletion before fat stores are exhausted.

Area of Science:

  • Metabolic adaptation
  • Comparative physiology
  • Obesity research

Background:

  • Mammals and birds conserve protein during fasting by mobilizing fat.
  • This strategy shifts to increased protein utilization and foraging behaviors as fasting prolongs.
  • The impact of severe obesity on these fasting adaptation patterns is not well understood.

Purpose of the Study:

  • To investigate the effect of severe obesity on protein loss patterns during long-term fasting.
  • To compare protein utilization and conservation strategies in obese versus lean Zucker rats.

Main Methods:

  • Utilized Zucker rats, a model for severe obesity, for long-term fasting studies.
  • Monitored nitrogen excretion, energy expenditure from protein, and daily protein loss in muscles.

Related Experiment Videos

  • Assessed changes in body composition and lipid reserves at the study's end.

    • Main Results:

    • Obese rats exhibited significantly lower daily nitrogen excretion and protein utilization compared to lean rats.
    • The protein-sparing phase was nine times longer in obese rats.
    • Despite better protein conservation, total body protein loss was higher in obese rats (57% vs. 29%).
    • Obese rats retained more lipid reserves (18%) than lean rats (2%) at study's end.

    Conclusions:

    • Severe obesity alters fasting adaptation, enhancing protein conservation but leading to greater cumulative protein loss.
    • Obese individuals may reach lethal protein depletion before exhausting fat reserves, unlike lean individuals who rely on lipid fuels for survival.
    • Findings highlight critical differences in metabolic response to fasting in obesity.