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Updated: Aug 25, 2026

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
Published on: November 30, 2021
Bladder wall necrosis in an extremely low-birth-weight infant: a thought-provoking complication of necrotizing
Jonathan R Swanson1, Jonathan M Ciambotti, Bradley M Rodgers
1Department of Pediatrics, University of Virginia Health System, Charlottesville, VA 22908, USA.
Abstract:
An 879-g baby boy had catastrophic necrotizing enterocolitis (NEC) at 29 days of life and underwent surgical laparotomy with a subsequent ileostomy and peritoneal drain placement. The infant was subsequently stable until 42 days of life when a spontaneous perforation of the bladder apex was diagnosed by a suprapubic cystogram. Laparotomy on day of life 46 found a loop of dead bowel herniating into a necrotic hole of the bladder dome. This case shows a previously unreported complication of NEC and discusses the possibility that prolonged use of a peritoneal drain may have permitted its genesis.
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