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Updated: Aug 25, 2026
Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
Published on: November 26, 2015
Androgen receptor protein expression in prostatic tissues in Black and Caucasian men
E Oluwabunmi Olapade-Olaopa1, Charles A Muronda, E Hugh MacKay
1Department of Urology, Leicester General Hospital, Leicester, United Kingdom. okeoffa@yahoo.com
Background:
CaP has a higher incidence and mortality in Black men. We hypothesized that subpopulation differences in AR expression may contribute to this phenomenon.
Method:
AR immunostaining was compared in epithelium and PES of normal, BPH, and CaP tissues from Black African men and UK Caucasian men.
Results:
AR expression was similar in normal prostatic epithelium of both groups, but was higher in BPH and CaP epithelium of Black than Caucasian men (P
Conclusions:
Variations in AR expression between subpopulations may contribute to the phenotypic differences of prostatic diseases in Black and Caucasian men.
