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[Clinical picture of celiac disease in children]

T E Lavrova

    Eksperimental'Naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology
    |April 7, 2004
    PubMed

    Insights

    Celiac disease, a chronic intestinal disorder, was first identified in the late 19th century. Its link to gluten intolerance was established in 1950, leading to its recognition as gluten enteropathy.

    Area of Science:

    • Gastroenterology
    • Pediatrics
    • Clinical Medicine

    Context:

    • Celiac disease has a history spanning over a century, initially observed as a growth and malabsorption syndrome in children.
    • Early descriptions by Gee and Herter focused on enteropathies, with the large intestine mistakenly implicated.
    • The critical role of gluten in chronic intestinal disease was first identified by Dutch pediatrician W. Dicke in 1950.

    Purpose:

    • To provide a historical overview of the understanding and naming of celiac disease.
    • To highlight key milestones in the identification of its etiology and associated symptoms.
    • To establish the etymological connections and synonyms for celiac affection.

    Summary:

    • Celiac disease was first described in 1888 by S. Gee, who noted growth inhibition and malabsorption in children.
    • Initially termed 'celiac affection,' the condition was later described as 'intestinal infantilism' by C. Herter.
    • W. Dicke's 1950 discovery linked gluten intolerance to chronic childhood intestinal disease, leading to synonyms like gluten enteropathy.

    Impact:

    • Recognizing gluten as the causative agent revolutionized the understanding and management of celiac disease.
    • The historical progression of its description underscores the evolution of clinical observation and diagnostic capabilities.
    • Synonyms like gluten intolerance and non-tropical sprue reflect the diverse historical perspectives on this condition.

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