Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Computational model to evaluate port wine stain depth profiling using pulsed photothermal radiometry.

Bernard Choi1, Boris Majaron, J Stuart Nelson

  • 1University of California, Beckman Laser Institute, Irvine, California 92612, USA. bchoi@laser.bli.uci.edu

Journal of Biomedical Optics
|April 7, 2004
PubMed
Summary

Pulsed photothermal radiometry (PPTR) effectively profiles port wine stain (PWS) skin depth. This optical-thermal model accurately extracts key PWS characteristics, validating PPTR for PWS assessment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of the β correction factor on the accuracy of speckle contrast imaging measurements.

Biomedical optics express·2026
Same author

Optical and acoustic scattering in cutaneous neurofibromas: Implications for early detection.

The Journal of investigative dermatology·2026
Same author

Comparative Evaluation of R134a and HFO-1234ze Cryogen Spray Cooling Using a Mouse Model With Controllable Epidermal Pigmentation.

Lasers in surgery and medicine·2026
Same author

Two-step regression analysis approach to assess burn wound severity using spatial frequency domain imaging.

Journal of biomedical optics·2026
Same author

Effects of O<sup>+</sup> and a Non-O<sup>+</sup> Blood Type, Number Concentration, and Membrane Phosphatidylserine Flipping on the Circulation Dynamics and Biodistribution of Microsized Erythrocyte-Derived Optical Particles in Mice.

ACS applied bio materials·2025
Same author

Flashes of Light: From the Lab and Dermatopathology, to the World With Marty Mihm.

Journal of cutaneous pathology·2025

Area of Science:

  • Biomedical Optics
  • Dermatology
  • Medical Imaging

Background:

  • Port wine stain (PWS) is a common vascular malformation.
  • Accurate depth profiling of PWS is crucial for effective treatment.
  • Non-invasive methods for PWS characterization are highly desirable.

Purpose of the Study:

  • To develop and evaluate an optical-thermal model for pulsed photothermal radiometry (PPTR).
  • To assess the capability of PPTR for depth profiling of port wine stain (PWS) skin.
  • To determine the accuracy of PPTR in extracting key PWS skin characteristics.

Main Methods:

  • Development of an optical-thermal model using digitized PWS biopsy histology.
  • Simulation of laser-induced temperature profiles from digitized skin geometry.

Related Experiment Videos

  • Reconstruction of temperature profiles from simulated PPTR signals using an iterative algorithm.
  • Evaluation of PWS skin characteristics: epidermal thickness, epidermal temperature rise, PWS upper boundary depth, and maximum temperature rise depth.

    • Main Results:

    • The optical-thermal model successfully reconstructed temperature profiles from simulated PPTR signals.
    • Accurate extraction of four key PWS skin characteristics was achieved.
    • Comparison showed a good match between actual and reconstructed PWS skin profiles.
    • The study validated the feasibility of PPTR for PWS depth profiling.

    Conclusions:

    • Pulsed photothermal radiometry (PPTR) is a viable non-invasive technique for PWS depth profiling.
    • The developed optical-thermal model provides a robust framework for PPTR analysis in PWS.
    • PPTR shows promise for improving diagnostic accuracy and treatment planning for PWS.