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Related Experiment Videos

Lessons from the porcine enteric nervous system.

D R Brown1, J-P Timmermans

  • 1Department of Veterinary PathoBiology, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, USA. brown013@umn.edu

Neurogastroenterology and Motility
|April 7, 2004
PubMed
Summary

Pigs have a complex enteric nervous system similar to humans, differing significantly from guinea pigs. This highlights the pig as a valuable model for developing treatments for human neurogastrointestinal disorders.

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Area of Science:

  • Gastroenterology
  • Neuroscience
  • Pharmacology

Background:

  • The porcine intestinal tract shares functional and pathological similarities with the human digestive tract.
  • The enteric nervous system (ENS) organization in pigs is more complex than in commonly studied animals like guinea pigs.

Purpose of the Study:

  • To investigate the differences in intrinsic primary afferent neurons between large and small animals.
  • To characterize opioid receptor subtypes and their distribution in the porcine enteric nervous system.
  • To evaluate the suitability of the pig as an animal model for human neurogastrointestinal disorders.

Main Methods:

  • Comparative analysis of enteric nervous system organization.
  • Electrophysiological studies of neurons.

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  • Pharmacological characterization of opioid receptors in different intestinal regions.

    • Main Results:

    • Intrinsic primary afferent neurons exhibit variations in chemical coding, distribution, electrophysiology, and synaptic properties between species.
    • Opioid receptors in the porcine small intestine are predominantly delta-type, unlike the mu-type found in guinea-pig ileum.
    • Delta-opioid receptors in porcine ileum modulate smooth muscle contraction and mucosal ion transport with distinct pharmacological profiles.

    Conclusions:

    • Significant interspecies and interregional differences exist in the enteric nervous system.
    • The pig represents a homologous animal model for studying human neurogastrointestinal disorders.
    • Drug development for human neurogastrointestinal conditions should leverage findings from porcine models.