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Published on: June 9, 2011
[Meningitis by Toscana virus in Spain: description of 17 cases]
José María Navarro1, Concepción Fernández-Roldán, Mercedes Pérez-Ruiz
1Servicio de Microbiología. Hospital Universitario Virgen de las Nieves. Granada. España. josem.navarro.sspa@juntadeandalucia.es
Background And Objective:
We aimed to analyze the clinical and epidemiological data from the first series of patients with meningitis by Toscana virus in Spain.
Patients And Method:
We analyzed a total of 724 cerebrospinal fluid (CSF) samples from patients with suspicion of aseptic meningitis for virus isolation in cell culture. The clinical records of patients in whom Toscana virus was isolated were analyzed.
Results:
Toscana virus was isolated in CSF in 17 patients (7% of all viral isolates). The first case was diagnosed in June 1988 and the last one in August 2002. The mean age was 27 years (range: 10-64 years). Most patients were based in rural area (n = 11, 64.7%). Most common symptoms were headache (holocranial or focal) present in all patients and moderate fever observed in 76.5% of them with a mean duration of 48 h (range: 18 h-5 days). Nuchal rigidity was present in 9 patients (53%). All cases were seen between June and October, and predominantly in August (53%). The outcome was favorable in all cases, and the mean time of duration of the disease was 7 days (range: 3-10 days).
Conclusions:
Toscana virus must be taken into account among those agents responsible of lymphocytic meningitis in Spain.
Insights
Toscana virus causes lymphocytic meningitis in Spain. This study analyzed 17 cases, noting symptoms like headache and fever, with favorable outcomes in all patients.
Area of Science:
- Virology
- Epidemiology
- Neurology
Context:
- Toscana virus is an emerging cause of meningitis.
- Limited data exists on Toscana virus meningitis in Spain.
Purpose:
- To analyze the clinical and epidemiological features of Toscana virus meningitis.
- To identify the prevalence and characteristics of Toscana virus infections in Spain.
Summary:
- Toscana virus was isolated from 17 patients (7% of viral isolates) with aseptic meningitis in Spain between 1988 and 2002.
- Patients, with a mean age of 27, predominantly resided in rural areas and presented with headache, fever, and nuchal rigidity.
- All cases occurred between June and October, with favorable outcomes and a mean disease duration of 7 days.
Impact:
- Highlights Toscana virus as a significant cause of lymphocytic meningitis in Spain.
- Provides crucial data for understanding the epidemiology and clinical presentation of Toscana virus infections.
- Informs public health strategies for meningitis prevention and control.
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