Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dietary cholesterol affects sympathetic nerve function in rabbit hearts.

Tsai-Yueh Luo1, Chau-Chung Wu, Yen-Bin Liu

  • 1Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.

Journal of Biomedical Science
|April 7, 2004
PubMed
Summary

High cholesterol in rabbits increases cardiac sympathetic nerve density. This leads to reduced response to isoproterenol but enhanced response to norepinephrine in the heart.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Impact of a Visualized Steerable Sheath on Radiofrequency Catheter Ablation for First-Time Atrial Fibrillation Ablation: A Prospective, Randomized, Single-Blind Study.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2026
Same author

Response to "Comment on 'recent trends of LDL-C control and lipid-lowering therapy in patients with ASCVD in Taiwan: 2015-2020".

Journal of the Formosan Medical Association = Taiwan yi zhi·2026
Same author

Double-Snare Retrieval and Mapping-Guided Reimplantation of a Dislodged Atrial Leadless Pacemaker.

JACC. Case reports·2026
Same author

Generalisable artificial intelligence ECG trained on public data for outcome prediction after transcatheter aortic valve replacement.

Heart (British Cardiac Society)·2026
Same author

Nanomedicine-based theranostics in atherosclerotic cardiovascular diseases.

Journal of biomedical science·2026
Same author

Glycemic control and renal function decline in patients with chronic coronary syndrome: A multicenter cohort study.

Journal of diabetes investigation·2026

Area of Science:

  • Cardiovascular Physiology
  • Neurocardiology
  • Metabolic Research

Background:

  • Hypercholesterolemia is a risk factor for cardiovascular diseases.
  • Cardiac sympathetic nerve function plays a crucial role in heart regulation.
  • The impact of hypercholesterolemia on cardiac neural remodeling requires further investigation.

Purpose of the Study:

  • To investigate the effects of hypercholesterolemia on cardiac sympathetic nerve function and density in rabbits.
  • To evaluate changes in myocardial (123)I-meta-iodobenzylguanidine ((123)I-MIBG) uptake and washout.
  • To assess the inotropic responses to adrenergic agonists in hypercholesterolemic hearts.

Main Methods:

  • New Zealand white rabbits were fed a cholesterol-enriched or normal diet for 3 months.

Related Experiment Videos

  • Serial cardiac imaging with (123)I-MIBG was performed to assess myocardial uptake and washout.
  • In vitro studies evaluated the inotropic responses of isolated right ventricular strips to isoproterenol and norepinephrine.

    • Main Results:

    • Hypercholesterolemic rabbits showed increased cardiac (123)I-MIBG uptake (heart to mediastinum ratio).
    • No significant difference in (123)I-MIBG washout ratios was observed between groups.
    • In vitro, hypercholesterolemic myocardium exhibited enhanced norepinephrine response (with cocaine) and reduced isoproterenol response.

    Conclusions:

    • Hypercholesterolemia induces neural remodeling in the rabbit myocardium, increasing sympathetic nerve density.
    • These neural changes alter the heart's response to adrenergic stimulation.
    • The findings highlight the functional significance of hypercholesterolemia-induced neural remodeling in the heart.