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Effects of some natural products on sugar cataract studied with nuclear magnetic resonance spectroscopy
G C Chiou1, N J Stolowich, Y Q Zheng
1Institute of Ocular Pharmacology, Texas A&M University, College Station.
Journal of Ocular Pharmacology
|January 1, 1992
Abstract:
Four commercial anticataract drugs and five flavonoids isolated from Chinese herbs were studied on their effects to inhibit sugar cataract formation in vitro using 13C-nuclear magnetic resonance spectroscopy (MRS). Pa-Wei-Di-Huan-Wan (PWDHW) and Zhang-Yan-Ming (ZYM) were effective in inhibiting sorbitol formation, whereas Bai-Nei-Ting (BNT) and Pearl Min-Mu-Ye (Pearl MMY) were ineffective in inhibiting sorbitol formation. Among five flavonoids tested, four were moderately effective in inhibiting sorbitol formation, and one was totally ineffective up to 1 x 10(-4)M used.