Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Precorneal sampling techniques for ophthalmic gels.

S Ding1, C C Chen, R Salome-Kesslak

  • 1Allergan, Inc. Irvine, California.

Journal of Ocular Pharmacology
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Morphine augmentation increases gallbladder visualization in patients pretreated with cholecystokinin.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·1997
Same author

Right-sided cardiac tumors detected by transesophageal echocardiography and its usefulness in differentiating the benign from the malignant ones.

The American journal of cardiology·1997
Same author

Postoperative MRI of anorectal malformation.

Journal of the Formosan Medical Association = Taiwan yi zhi·1997
Same author

Collagen synthesis in idiopathic and dilantin-induced gingival fibromatosis.

The Kaohsiung journal of medical sciences·1997
Same author

Value of somatostatin receptor scintigraphy: a prospective study in gastrinoma of its effect on clinical management.

Gastroenterology·1997
Same author

Blood levels of reduced haloperidol versus clinical efficacy and extrapyramidal side effects of haloperidol.

Progress in neuro-psychopharmacology & biological psychiatry·1997
Same journal

Systemic delivery of polypeptide drugs through ocular route.

Journal of ocular pharmacology·1994
Same journal

Mucoadhesive ophthalmic vehicles: evaluation of polymeric low-viscosity formulations.

Journal of ocular pharmacology·1994
Same journal

The role of iontophoresis in ocular drug delivery.

Journal of ocular pharmacology·1994
Same journal

Ion exchange resins for ophthalmic delivery.

Journal of ocular pharmacology·1994
Same journal

In situ-forming gels for ophthalmic drug delivery.

Journal of ocular pharmacology·1994
Same journal

A rationale for gene targeting in glaucoma therapy.

Journal of ocular pharmacology·1994
See all related articles

Determining ocular drug delivery contact time for ophthalmic gels is crucial. Capillary tubes proved effective for sampling precorneal drug concentration, revealing contact times of approximately one hour.

Area of Science:

  • Ophthalmology
  • Pharmaceutics
  • Drug Delivery

Background:

  • Drug-cornea contact time is vital for ocular drug efficacy.
  • Existing methods for determining this are limited, primarily for eye drops and ointments, not ophthalmic gels.
  • No established methods exist for quantifying precorneal drug concentration over time for ophthalmic gels.

Purpose of the Study:

  • To evaluate tear film sampling techniques for determining precorneal drug concentration over time with ophthalmic gels.
  • To assess the suitability of capillary tubes, Schirmer strips, and cotton swabs for this purpose.
  • To establish the drug-cornea contact time for a specific polyacrylate-based pilocarpine HCl gel.

Main Methods:

  • Utilized a rabbit eye model to study a commercial polyacrylate-based pilocarpine HCl ophthalmic gel.

Related Experiment Videos

  • Evaluated two tear film sampling techniques: capillary tubes and Schirmer strips.
  • Assessed one recovery technique: cotton swab for total drug recovery.

    • Main Results:

    • All three techniques yielded similar precorneal drug-cornea contact times, around one hour.
    • Capillary tubes enabled successful tear sampling and revealed nonuniform drug distribution at early time points (10 and 30 minutes).
    • Schirmer strips showed a gel-carry-over issue, making them less suitable for early-stage sampling; cotton swabs were gentle but did not provide tear film data.

    Conclusions:

    • Capillary tubes are recommended for accurate precorneal drug concentration determination in ophthalmic gel studies.
    • The evaluated pilocarpine HCl gel has a drug-cornea contact time of approximately one hour.
    • Understanding drug distribution and contact time is essential for optimizing ophthalmic gel formulations.