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Published on: August 24, 2018
[Growth-suppression effect of hydroxyurea on meningioma cells in vitro]
Shu-xu Yang1, Yi-rong Wang, Hai-peng Gan
1Department of Neurosurgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China. yangshuxu5@hotmail.com
Objective:
To investigate the tumor-suppression effect of hydroxyurea on meningioma cells and its possible mechanism.
Methods:
The meningioma cells were cultured in medium containing varied doses of hydroxyurea (5x10(-3)mol/L, 5x10(-4)mol/L, 5x10(-5)mol/L), the cell growth was measured by MTT method, cell apoptosis was observed with flow cytometry (FCM).
Results:
MTT measurement demonstrated that the administration of hydroxyurea led to a dose-dependent suppression in cell proliferation and FCM showed a dose-dependent increase in apoptosis rate.
Conclusion:
Hydroxyurea can inhibit meningioma cell growth in vitro, which is most likely associated with apoptosis of the tumor cells.
