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Management of chronic hepatitis B in the HIV-infected patient

Chloe L Thio1

  • 1Johns Hopkins University, Baltimore, Maryland, USA.

The AIDS Reader
|April 8, 2004
PubMed

Coinfection with HIV and hepatitis B virus (HBV) is common because of their shared modes of transmission. HIV infection alters the natural history of HBV infection, leading to more severe liver disease, decreased hepatitis B e antigen seroconversion, and higher HBV DNA levels. Furthermore, end-stage liver disease has emerged as a common cause of morbidity and mortality in HIV-infected persons receiving HAART. For these reasons, it is important to vaccinate susceptible persons against HBV infection and to diagnose and treat chronic hepatitis B in HIV-infected persons. The treatment plan for chronic hepatitis B needs to be individualized based on the stage of both viral infections and the available options. It is anticipated that we are entering a period of combination therapy for chronic hepatitis B, but the ideal combination needs to be elucidated.

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