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High pressure: a promising tool for multicomponent reactions.

Leon W A van Berkom1, George J T Kuster, Hans W Scheeren

  • 1Department of Organic Chemistry, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.

Molecular Diversity
|April 8, 2004
PubMed
Summary

High pressure significantly expands the possibilities for multicomponent reactions, enabling unique transformations. This study reviews high-pressure catalyzed reactions, including domino cycloadditions.

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Area of Science:

  • Organic Chemistry
  • Reaction Engineering

Background:

  • Multicomponent reactions (MCRs) offer efficient synthetic routes.
  • The scope of MCRs is often limited by reaction conditions.
  • High pressure is an underexplored parameter in MCRs.

Purpose of the Study:

  • To discuss the application of high pressure in multicomponent reactions.
  • To highlight MCRs that benefit from or require high pressure.
  • To provide an overview of high-pressure catalyzed MCRs.

Main Methods:

  • Literature review of high-pressure catalyzed MCRs.
  • Focus on reactions enabled exclusively by high pressure.
  • Detailed examination of domino cycloaddition reactions.

Main Results:

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  • High pressure can increase the scope and efficiency of MCRs.
  • Certain MCRs are only feasible under high-pressure conditions.
  • Domino [4 + 2]/[3 + 2] cycloaddition is a key example.

Conclusions:

  • High-pressure catalysis is a powerful tool for advancing MCRs.
  • This technique unlocks novel synthetic pathways.
  • Further exploration of high pressure in MCRs is warranted.