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Related Experiment Videos

Harmonic imaging improves estimation of left ventricular mass.

James C S Spratt1, Stephen J Leslie, Audrey White

  • 1Department of Cardiology, Western General Hospital, The University of Edinburgh, Edinburgh EH4 2XU, UK.

The International Journal of Cardiovascular Imaging
|April 8, 2004
PubMed
Summary

Tissue harmonic imaging (THI) provides more accurate left ventricular mass index (LVMI) measurements by M-mode echocardiography in hypertensive males compared to fundamental imaging (FI). FI significantly underestimates LVMI when compared to MRI, suggesting current reference ranges may not apply with THI.

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Area of Science:

  • Cardiology
  • Medical Imaging
  • Diagnostic Ultrasound

Background:

  • Left ventricular mass index (LVMI) is a crucial metric for assessing cardiac health, particularly in hypertensive individuals.
  • M-mode transthoracic echocardiography is a common tool for LVMI assessment, but its accuracy can be influenced by imaging techniques.
  • Tissue harmonic imaging (THI) is an advanced ultrasound technology that may improve image quality and diagnostic accuracy.

Purpose of the Study:

  • To evaluate the impact of tissue harmonic imaging (THI) on M-mode echocardiography measurements of left ventricular mass index (LVMI).
  • To compare THI-based LVMI measurements with those obtained using fundamental imaging (FI) and magnetic resonance imaging (MRI).

Main Methods:

  • Twenty hypertensive male subjects underwent LVMI measurement using gradient-echo MRI and M-mode transthoracic echocardiography.

Related Experiment Videos

  • Echocardiographic recordings were acquired using both fundamental imaging (FI) and tissue harmonic imaging (THI) in a randomized, blinded manner.
  • LVMI was calculated from MRI using Simpson's rule on serial short-axis slices; echocardiographic data were analyzed offline by a blinded observer.

    • Main Results:

    • A statistically significant difference was observed in LVMI measurements between FI and THI (79 ± 20 vs. 93 ± 25 g², p < 0.001).
    • THI demonstrated a lower mean difference compared to MRI (2 ± 15 g²) than FI (-32 ± 22 g², p < 0.001), indicating FI underestimates LVMI.
    • Inter-observer variability was comparable between THI and FI (4.5 ± 15 vs. 6.4 ± 15 g², p = 0.46).

    Conclusions:

    • M-mode echocardiography using fundamental imaging (FI) tends to underestimate left ventricular mass index (LVMI) in hypertensive males.
    • The findings suggest that established reference ranges for LVMI derived from FI may not be directly applicable when utilizing tissue harmonic imaging (THI).
    • THI may offer a more accurate assessment of LVMI compared to FI in this patient population.