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Antibiotic prophylaxis in clean neck dissections.

Huseyin Seven1, Ibrahim Sayin, Suat Turgut

  • 1Ear, Nose, and Throat Department, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.

The Journal of Laryngology and Otology
|April 8, 2004
PubMed
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Prophylactic ampicillin-sulbactam for 24 hours significantly reduced wound infections in clean neck dissection patients. This antibiotic regimen is effective in preventing post-operative wound infections.

Area of Science:

  • Surgical Oncology
  • Infectious Disease Prevention

Background:

  • Clean neck dissections carry a risk of post-operative wound infection.
  • Prophylactic antibiotics are sometimes used to mitigate surgical site infections.

Purpose of the Study:

  • To evaluate the efficacy of a 24-hour perioperative ampicillin-sulbactam regimen in reducing wound infection incidence after clean neck dissections.

Main Methods:

  • A prospective study compared 57 patients receiving perioperative ampicillin-sulbactam with 51 historical controls who received no antibiotics.
  • The primary outcome measured was the incidence of post-operative wound infection.

Main Results:

  • Wound infection occurred in 1.7% of patients in the antibiotic group versus 13.3% in the control group.

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  • This difference was statistically significant (p = 0.02).

    • Conclusions:

    • Perioperative antibiotic use for 24 hours significantly reduces the incidence of post-operative wound infection following clean neck dissections.
    • Ampicillin-sulbactam is an effective prophylactic agent for this surgical procedure.