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Updated: Aug 25, 2026

MicroRNA-based Regulation of Picornavirus Tropism
Published on: February 6, 2017
RNA silencing in viral infections: insights from poliovirus
Maria-Carla Saleh1, Ronald P Van Rij, Raul Andino
1Department of Microbiology and Immunology, University of California, 513 Parnassus Avenue, Box 0414, San Francisco, CA 94143-2280, USA.
Abstract:
RNA interference or RNA silencing is a dsRNA guided mechanism that mediates sequence specific degradation of RNA. The recent demonstration that RNA interference can be used to inhibit virus replication has initiated an exciting field of research: first, as a potential novel antiviral therapeutic approach and, second, as a tool for dissecting virus-host interactions. Here we review and discuss the current data and perspectives on the use of RNA interference in the study of poliovirus as a model for positive strand RNA viruses.
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