The properties of tablets containing microcrystalline cellulose

Area of Science:

• Pharmaceutical Sciences
• Materials Science

Background:

• Tablets are a common dosage form requiring careful formulation for optimal drug release.
• Microcrystalline cellulose (MCC) and lactose are widely used excipients in tablet manufacturing.

Purpose of the Study:

• To investigate the effect of microcrystalline cellulose (Avicel) concentration on tablet dissolution rate.
• To determine the optimal Avicel content for maximizing dissolution and liquid penetration.

Main Methods:

• Tablets were prepared using mixtures of microcrystalline cellulose (Avicel PH 101 and PH 105) and spray-dried lactose.
• Dissolution rate, liquid penetration rate, and pore structure were evaluated at varying Avicel concentrations.
• The impact of magnesium stearate and Carbowax 4000 on tablet properties was assessed.

Main Results:

• Dissolution rate increased with higher Avicel percentages, peaking at 4% w/w for PH 101 and 2% w/w for PH 105.
• The maximum dissolution rate correlated with maximum liquid penetration for PH 101.
• For PH 105, the optimum balance between disintegration and liquid penetration determined the peak dissolution.
• Magnesium stearate reduced dissolution by hindering water penetration, while Carbowax 4000 did not.

Conclusions:

• Avicel concentration significantly influences tablet dissolution rate and liquid penetration.
• The optimal Avicel grade and concentration are crucial for achieving desired tablet performance.
• Lubricant selection (e.g., magnesium stearate vs. Carbowax 4000) impacts water penetration and dissolution.