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Anti-inflammatory agents from Sandoricum koetjape Merr
M A Rasadah1, S Khozirah, A A Aznie
1Forest Research Institute Malaysia, Kepong, Kuala Lumpur, Malaysia. rasadah@frim.gov.my
Abstract:
The anti-inflammatory activity of the stem extracts of Sandoricum koetjape was investigated on topical administration using the TPA (tetradecanoylphorbol acetate)-induced mouse ear inflammation model. Bioassay-guided chromatographic fractionation of active fractions led to the isolation 3-oxo-12-oleanen-29-oic acid and katonic acid as the bioactive principles responsible for the anti-inflammatory acitivity. The percentage of inhibition exhibited by 3-oxo-12-oleanen-29-oic acid was almost equivalent to indomethacin.
