Performance evaluation of the complete blood count and white blood cell differential parameters obtained using a...

Performance of a new hematology analyzer, the Celltac F, MEK-8222 (Nihon Kohden, Tokyo, Japan), was evaluated. This analyzer simultaneously measures 22 parameters including leukocyte differentials. Within- and between-batch precision, linearity, and absence of carryover were all excellent. Accurate measurements of complete blood count parameters were possible during the 48-hour test periods for stability at 4 degrees C and room temperature. Automated differential parameters showed acceptable stability during the 24-hour test period. The performance was evaluated in comparison with the CD-4000 (Abbott, Abbott Park, IL, USA). There was a good correlation between findings with the Celltac F and those with the CD-4000 hematology analyzer for complete blood count parameters and leukocyte differential parameters other than percentages of basophils. Comparisons of differential leukocyte counts to microscopic differentials were excellent for neutrophils, lymphocytes, and eosinophils and were acceptable for monocytes. The clinical utility and flagging performance were excellent. The Celltac F is compact and it is able to process 80 samples per hour. The volumes of sample and reagent consumed were slight. The instrument has good potential to contribute to effective total cost management and to be a useful backup system with high throughput, while taking up minimal space in the clinical laboratory.