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Updated: Aug 24, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Enantioselective total synthesis of (-)-dehydrobatzelladine C. [structure: see text]
Shawn K Collins1, Andrew I McDonald, Larry E Overman
1Department of Chemistry, 516 Rowland Hall, University of California at Irvine, Irvine, CA 96697-2025, USA.
Abstract:
The oxidation of two tethered Biginelli adducts was examined as a potential key step in total syntheses of highly oxidized batzelladine and crambescidin alkaloids. Although angular hydroxyl substitution could not be introduced, dehydrogenation was readily accomplished. This latter conversion is a key step in the first total synthesis of dehydrobatzelladine C. [structure: see text]
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