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Related Experiment Videos

Functional evolution of the yeast protein interaction network.

Victor Kunin1, José B Pereira-Leal, Christos A Ouzounis

  • 1Computational Genomics Group, The European Bioinformatics Institute EMBL Cambridge Outstation, Cambridge, UK. kunin@ebi.ac.uk

Molecular Biology and Evolution
|April 9, 2004
PubMed
Summary
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The study reveals that protein interaction networks evolve over time, with more connected proteins emerging during eukaryotic radiation. Protein function evolution is key to understanding these network dynamics.

Area of Science:

  • Systems Biology
  • Evolutionary Biology
  • Bioinformatics

Background:

  • Protein interactions are fundamental to cellular functions.
  • Understanding the evolutionary emergence of protein interaction networks is crucial.

Purpose of the Study:

  • To investigate the dynamics of protein interaction network emergence in Saccharomyces cerevisiae.
  • To correlate protein connectivity with evolutionary periods and functional class emergence.

Main Methods:

  • Mapping protein origins onto an evolutionary tree.
  • Analyzing connectivity levels across different evolutionary periods.
  • Comparing connectivity of functional classes and their emergence times.

Main Results:

Related Experiment Videos

  • Evolutionary periods exhibit distinct protein connectivity levels.
  • Highly connected protein groups originated during eukaryotic radiation.
  • Pre-eukaryotic proteins are less connected than eukaryotic ones.
  • Functional classes show varying average connectivity, paralleling their evolutionary emergence.

    • Conclusions:

    • Protein function evolution likely drives connectivity differences over evolutionary time.
    • Understanding scale-free biological networks requires considering protein function.