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Updated: Aug 24, 2026

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
Published on: February 15, 2016
Isochroman derivatives and their tendency to crystallize in chiral space groups
Marcin Palusiak1, Arno Pfitzner, Manfred Zabel
1Department of Crystallography and Crystal Chemistry, University of Lodz, Pomorska 149/153, 90236 Łódź, Poland. marcinp@uni.lodz.pl
Abstract:
In methyl [5-methoxy-4-(4-methoxyphenyl)isochroman-3-yl]acetate, C(20)H(22)O(5), (I), and methyl [4-(2,5-dimethoxyphenyl)-8-methoxyisochroman-3-yl]acetate, C(21)H(24)O(6), (II), the heterocyclic rings adopt half-chair conformations. The substituents at the 3- and 4-positions are in a trans configuration in both (I) and (II), being in an axial conformation in (I) and in an equatorial conformation in (II). The crystal structure of (I) is stabilized by weak C-H.O hydrogen bonding, leading to the formation of an infinite three-dimensional network. Compound (II) crystallizes in a chiral space group. This feature, which was also found in previously investigated isochroman derivatives, is related to the arrangement of substituents attached to the isochroman moiety.
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