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A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
Published on: February 28, 2012
Cost-effectiveness of the implantable cardioverter defibrillator
Mark A Hlatky1, Gillian D Sanders, Douglas K Owens
1Department of Health Research and Policy, Stanford University School of Medicine, CA 94305-5405, USA. hlatky@stanford.edu
Insights
The implantable defibrillator (ICD) offers improved survival but at a high cost. Its cost-effectiveness is favorable in high-risk patients who gain at least six months of life.
Area of Science:
- Cardiovascular Medicine
- Health Economics
- Medical Technology Assessment
Background:
- High cost of implantable defibrillators (ICDs) raises concerns about clinical and economic justification.
- Previous randomized trials have investigated the economic outcomes of ICDs.
Purpose of the Study:
- To evaluate the cost-effectiveness of implantable defibrillators (ICDs) compared to conventional therapy.
- To identify patient subgroups where ICD use is economically attractive.
Main Methods:
- Analysis of economic outcomes from three randomized trials of ICDs.
- Calculation of cost-effectiveness (CE) ratios, measured in dollars per life year added.
Main Results:
- All trials showed higher costs for ICD patients versus conventional therapy over 3-6 years.
- ICD patients experienced improved survival across all trials.
- Calculated ICD cost-effectiveness ratios ranged from $27,000 to $139,000 per life year added.
Conclusions:
- Variability in cost-effectiveness ratios is linked to differences in life years gained by ICDs.
- ICDs are economically attractive when they extend mean survival by six months or more.
- Higher-risk patient subgroups are more likely to achieve this survival benefit, making ICDs more justifiable.
Abstract:
Many clinicians and policymakers are concerned whether use of the implantable defibrillator (ICD) is justified in view of its high cost. Three randomized trials of the ICD have reported economic outcomes. Each trial found a large difference in cost between patients assigned to an ICD versus patients assigned to conventional therapy that persisted over three to six years of follow-up. Each trial also found better survival among ICD patients, and calculated ICD cost-effectiveness (CE) ratios between 27,000 dollars per life year added and 139,000 dollars per life year added. The variability in the cost-effectiveness ratios among trials is mainly due to variability in the years of life added by the ICD among the trials and, by extension, among patient subgroups. A rough rule of thumb is that the ICD will be economically attractive when it prolongs mean survival by six months or more, which is attainable in higher risk patient subgroups.
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